The Low DoseThe GLP-1 price desk
Briefing

Trimi vs PlexusDx

$125/mo against $189/mo for tirzepatide. Which is worth it, and for whom.

Updated 2026-09-18

DISCLOSURE — Coreage Rx pays this desk a commission when a reader signs up through our link. It buys no ranking, no score and no deletions. Method: how we rate. Full terms: disclosure.

Both sell tirzepatide. Trimi costs $125 a month and PlexusDx costs $189, a difference of $64 a month or about $768 a year. The desk reads it as follows.

Trimi is lowest flat price with named pharmacies. PlexusDx is pharmacy transparency and genetic testing. They are not aimed at the same person, and the cheaper one is not automatically the right answer — though on this board it usually is.

Side by side

TrimiPlexusDx
Advertised from$125$129
Membership on topNoneNone
True monthly cost$125$189
Roughly, per year$1,500$2,268
Price includes medicationYesYes
Names its pharmacyYesYes
Our score4.6 / 54.4 / 5

Prices verified 2026-09-18. "True monthly cost" is what you are billed in month two, once any introductory rate has lapsed and any membership has renewed.

Where Trimi wins

  • The cheapest verified flat rate for compounded tirzepatide in this comparison.
  • Names its pharmacies with a licence number and offers a certificate of analysis — almost nobody else in this market does.
  • Price does not move as your dose is adjusted.
  • No membership fee stacked on the medication price.

Both headline prices are annual-plan rates. Confirm the month-to-month figure and the refund terms before prepaying twelve months.

Where PlexusDx wins

  • The most detailed pharmacy disclosure in this comparison — six named 503A partners.
  • Names its prescribing physicians along with their NPI numbers.
  • No membership fee, and flat pricing across the dose range.
  • Genetic and blood testing available alongside the prescription.

The advertised "from $129" is the programme floor. Budget $189/month for the compounded injection tier.

How they score

What we weighWeightTrimiPlexusDx
True monthly cost30%54.6
Price honesty20%4.84.5
Clinical support20%43.8
Pharmacy sourcing15%4.84.9
Cancelling15%4.24

Trimi scores higher overall at 4.6 out of 5. The weights are published on how we rate, and so is the note about which of these is our paid featured partner.

Which should you pick?

  • Pick Trimi if cost is the binding constraint. Over a year the gap is about $768, which is real money for the same class of medication.
  • Pick PlexusDx if what it does better matters to you — the most detailed pharmacy disclosure in this comparison — six named 503a partners.
  • If sourcing matters, note that Trimi publishes which pharmacy compounds its medication and PlexusDx does not.

The verdict

On the board, Trimi at $125 a month is the more defensible choice on arithmetic alone. PlexusDx earns its premium only if you will actually use what it does differently. Read the full reviews before deciding: Trimi and PlexusDx.

How they sit against everyone else

ProgrammeAdvertisedBilledGapVs board floor
Coreage Rx$149$199+$50+$74/mo
Trimi$125$125none
Ozari Health$125$125none
Fifty 410$133$133none+$8/mo
PlexusDx$129$189+$60+$64/mo
Ivím Health$199$199none+$74/mo
Zealthy$216$216none+$91/mo
Hims & Hers$199$238+$39+$113/mo
Coby Health$179$239+$60+$114/mo
Mochi Health$199$278+$79+$153/mo
Eden$199$298+$99+$173/mo
Lemonaid Health$229$348+$119+$223/mo

More from the desk

  • Trimi tirzepatide review

    Advertised at $125 and billed at $125 — no gap. Position 2 of 18 on our board.

  • PlexusDx tirzepatide review

    Advertised at $129, billed at $189. Position 5 of 18 on our board.

  • How to spot a bad seller

    The FDA sent more than 55 warning letters to online GLP-1 sellers in one day. Here is how to tell a licensed programme from the rest.

  • The twelve-month cost

    Month one is the cheapest month you will have. Here is the full-year arithmetic, including the costs nobody puts in the advert.

  • Cheapest right now

    Every programme sorted on what it bills, not what it advertises. Floor: $199/mo tirzepatide, $149/mo semaglutide.