PlexusDx vs Hims & Hers

Both sell tirzepatide. PlexusDx costs $189 a month and Hims & Hers costs $238, a difference of $49 a month or about $588 a year. The desk reads it as follows.

PlexusDx is pharmacy transparency and genetic testing. Hims & Hers is widest range of formats. They are not aimed at the same person, and the cheaper one is not automatically the right answer — though on this board it usually is.

Advert against bill. PlexusDx advertises $129 and bills $189; Hims & Hers advertises $199 and bills $238. The gaps are different sizes, which means comparing the two on their advertised prices gives you the wrong answer.

Side by side

Prices verified 2026-09-18. "True monthly cost" is what you are billed in month two, once any introductory rate has lapsed and any membership has renewed.

The split

They differ on 3 of the 7 things we track, and behave the same on the other 4. The differences are what the price gap is actually buying.

What each puts on the record: PlexusDx

• GLP-1 weight-loss programmes start at $129/month.
• Compounded semaglutide injection listed at $189/month with no membership fee and the same price at every dose.
• A $189/month microdose tier is offered for compounded semaglutide or tirzepatide.
• No membership or platform fee is charged alongside the medication.
• Publicly names six 503A pharmacy partners: Belmar, Strive, Epiq Scripts, Casa Pharma Rx, The Pharmacy Hub and Foothills.
• Clinical oversight via LionMD, with named physicians and NPI numbers published.
• Licensed providers in all 50 states; CLIA-certified labs for its testing line.

Where it wins: The most detailed pharmacy disclosure in this comparison — six named 503A partners. Watch for: The advertised "from $129" is the programme floor. Budget $189/month for the compounded injection tier.

What each puts on the record: Hims & Hers

• Weight-loss membership advertised at $39 for the first month.
• Compounded GLP-1 injections priced from $199/month.
• Oral medication kits priced from $79/month.
• Branded Zepbound offered at $1,899/month.
• Company has announced oral semaglutide pricing starting around $49/month, with the 1.5 mg dose around $149/month.

Where it wins: One account covers oral, compounded injectable and branded options. Watch for: The advertised entry prices and the membership are separate charges. Add $39/month to whatever medication figure you were quoted.

In each one’s favour

PlexusDx.

• The most detailed pharmacy disclosure in this comparison — six named 503A partners.
• Names its prescribing physicians along with their NPI numbers.

Hims & Hers.

• One account covers oral, compounded injectable and branded options.
• Large enough to keep supply steady when smaller sellers run dry.

How they score

PlexusDx scores higher overall at 4.4 out of 5. The weights are published on how we rate, and so is the note about which of these is our paid featured partner.

The desk’s call

• Pick PlexusDx if cost is the binding constraint. Over a year the gap is about $588, which is real money for the same class of medication.
• Pick Hims & Hers if what it does better matters to you — one account covers oral, compounded injectable and branded options.
• If sourcing matters, note that PlexusDx publishes which pharmacy compounds its medication and Hims & Hers does not.

The verdict

On the board, PlexusDx at $189 a month is the more defensible choice on arithmetic alone. Hims & Hers earns its premium only if you will actually use what it does differently. Read the full reviews before deciding: PlexusDx and Hims & Hers.

How they sit against everyone else